Genetics and Outcome of Atypical Hemolytic Uremic Syndrome: A Nationwide French Series Comparing Children and Adults
Clinical Journal of the American Society of Nephrology, April 12, 2013
Fremeaux-Bacchi V et al. - Atypical hemolytic uremic syndrome (ahus) is a rare complement-mediated kidney disease that was first recognized in children but also affects adults. This study assessed the disease presentation and outcome in a nationwide cohort of patients with ahus according to the age at onset and the underlying complement abnormalities. Mortality rate was higher in children than adults with ahus, but renal prognosis was worse in adults than children. In ...
Shiga toxin 2 reduces complement inhibitor CD59 expression on human renal tubular epithelial and glomerular endothelial cells
Infection and Immunity, May 21, 2013
Ehrlenbach S et al. - Infections with enterohemorrhagic Escherichia coli (EHEC) are a primary cause of hemolytic uremic syndrome (hus). Recently, Shiga toxin 2 (Stx2), the major virulence factor of EHEC, was reported to interact with complement, implying that the latter is involved in the pathogenesis of EHEC-induced hus. Stx2 downregulates CD59 on mRNA and protein levels on tubular epithelial and glomerular endothelial cells, which likely contributes to complement activation and ...
Intestinal bacteria protect against E. coli O157:H7
ScienceDaily, May 22, 2013
A cocktail of non-pathogenic bacteria naturally occurring in the digestive tract of healthy humans can protect against a potentially lethal E. coli infection in animal models according to research presented at the 113th General Meeting of the American Society for Microbiology. The research, conducted by scientists at the University of Michigan Medical School in Ann Arbor, could have important implications for the prevention or even treatment of this disease. Enterohemorrhagic Escherichia ...
Multiple-to-Multiple Relationships between MicroRNAs and Target Genes in Gastric Cancer
PLOS ONE, May 13, 2013
Hashimoto Y et al. - MicroRNAs (miRNAs) act as transcriptional regulators and play pivotal roles in carcinogenesis. According to miRNA target databases, one miRNA may regulate many genes as its targets, while one gene may be targeted by many miRNAs. These findings indicate that relationships between miRNAs and their targets may not be one-to-one. hus, it is likely that the relationships between miRNAs and their targets are not one-to-one but ...
Head Computed Tomographic measurement as an early predictor of outcome in hypoxic-ischemic brain damage patients treated with hypothermia therapy
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, May 15, 2013
Yamamura H et al. - Neurological abnormalities are a key factor in the prognosis of patients with post-cardiac arrest syndrome. In this study, the authors evaluated whether differences in CT measurements expressed in Hounsfield units (hus) of the cerebral cortex and white matter can be used as early predictors of neurological outcome in patients treated with hypothermia therapy after hypoxic-ischemic brain damage. This study showed that DCW values may be used for the ...
Impact of platelet transfusions in children with post-diarrheal hemolytic uremic syndrome
Pediatric Nephrology, May 1, 2013
Balestracci A et al. - As this possibility has not yet been explored, the authors investigated whether platelet transfusion in patients with post-diarrheal hemolytic uremic syndrome (D + hus) would lead to a worse disease course compared to that in patients who did not receive platelet transfusion. The authors' findings suggest that platelet transfusion does not aggravate the course of the disease. Conversely, no hemorrhagic complications were observed in the group of patients who ...