Anaphylaxis in infancy compared with older children
Allergy and Asthma Proceedings, May 8, 2013
Topal E et al. – Although there has been increasing data on pediatric anaphylaxis, information about anaphylaxis in the 1st year of life is scarce. This study provides detailed information on clinical signs and symptoms of anaphylaxis in the 1st year of life. anaphylaxis in infants is not rare but many signs of anaphylaxis are overlooked and still undertreated.
A retrospective review was performed of the pediatric allergy database between 2007 and 2011.
Children who met the ...
Characteristics of anaphylaxis in children referred to a tertiary care center
Allergy and Asthma Proceedings, May 9, 2013
Vezir E et al. - anaphylaxis is a potentially life-threatening condition. There are limited data about the etiology and the clinical characteristics in developing countries. This study aimed to investigate the clinical characteristics of anaphylaxis patients attending the pediatric allergy clinic. Food and bee venom allergy were the most common etiologies. Adrenaline, the first-line treatment of anaphylaxis, was administered in only 44.4% of the cases.
IgE-mediated anaphylaxis and allergic reactions to idursulfase in patients with Hunter syndrome
Allergy, May 2, 2013
Kim J et al. - The purpose was to evaluate the occurrence of infusion-related allergic reactions, including anaphylaxis, to idursulfase in patients with MPS II receiving ERT and to elucidate its possible mechanism. anaphylaxis related to infusion of idursulfase is mediated by anti-idursulfase IgE antibody, which might be produced by de novo synthesis. SPT is useful in predicting the occurrence of anti-idursulfase IgE-mediated anaphylaxis during infusion.
Age-dependent sting recurrence and outcome in immunotherapy-treated children with anaphylaxis to Hymenoptera venom
Clinical & Experimental Allergy, May 6, 2013
Stritzke A et al. - The authors investigated the rate of sting recurrence and outcome of Hymenoptera venom anaphylaxis in children of different age groups treated with immunotherapy. A majority of children with anaphylaxis to Hymenoptera venom (56%) in the cohort were re-stung, equally by honey bees or Vespula species. Younger children were more likely to be re-stung but less likely to have a systemic reaction. Venom immunotherapy induces long-term protection in most ...
Customizing Anaphylaxis Guidelines for Emergency Medicine
The Journal of Emergency Medicine, May 3, 2013
Nowak R et al. - Develop a simple, consistent definition of anaphylaxis for emergency medicine providers, supported by clinically relevant consensus statements. The authors believe that this working definition and the supporting Consensus Statements are a first step to better management of anaphylaxis in the emergency medical setting.
Biphasic reactions in children undergoing oral food challenges
Allergy and Asthma Proceedings, May 10, 2013
Lee J et al. – The authors aimed to determine the prevalence of biphasic reactions in children with food allergies undergoing oral food challenges (OFCs) and examine whether any clinical or treatment factors are associated with biphasic reactions. A higher percentage of biphasic reactors also appeared to have received epinephrine, multiple doses of epinephrine, and antihistamines for their initial reactions. Biphasic reactions are rare in children undergoing OFCs and may be associated with ...
Galactose-alpha-1,3-galactose and Delayed Anaphylaxis, Angioedema, and Urticaria in Children
Pediatrics, May 6, 2013
Kennedy JL et al. – A novel form of anaphylaxis and urticaria that occurs 3 to 6 hours after eating mammalian meat is not uncommon among children in area. Identification of these cases may not be straightforward and diagnosis is best confirmed by specific testing, which should certainly be considered for children living in the area where the Lone Star tick is common. Methods Patients aged 4 to 17 were enrolled in an institutional review board–approved protocol at the University of ...
ASCIA guidelines for prevention of anaphylaxis in schools, pre-schools and childcare: 2012 update
Journal of Paediatrics and Child Health, May 16, 2013
Vale S et al. - Risk-minimisation strategies recommended take into consideration the needs of the allergic child; effectiveness of measures; stresses on parents and staff, the allergic child and their peers; and the implications of the recommended risk-minimisation strategies. These Guidelines address risk-minimisation strategies for food, insect and medication allergies; however, the majority of strategies relate to food allergy due to the higher risk of exposure in ...
Serum Gliadin Monitoring Extracts Patients with False Negative Results in Challenge Tests for the Diagnosis of Wheat-Dependent Exercise-Induced Anaphylaxis
Allergology International, May 2, 2013
Kohno K et al. - Challenge testing with wheat plus exercise and/or aspirin is a gold standard for the diagnosis of wheat–dependent exercise–induced anaphylaxis (WDEIA); however, the test may often yield false–negative results. The authors sought to extract the patients with false negative results in the challenge tests of WDEIA. The study revealed that serum gliadin monitoring during challenge testing is useful. Methods Thirty-six patients with suspected WDEIA were enrolled. ...
Recommendations for the management of beta-lactam intolerance
Clinical Reviews in Allergy and Immunology, April 11, 2013
Macy E et al. - Beta-lactam intolerance, most of which is not IgE or even immunologically mediated even though it is commonly called an “allergy,” can be safely managed using the following seven steps:
Avoid testing, re-challenging, or desensitizing individuals with histories of beta-lactam associated toxic epidermal necrolysis, Stevens–Johnson syndrome, drug reaction with eosinophilia and systemic symptoms syndrome, severe hepatitis, interstitial nephritis, or ...