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Exelixis, Inc. and Bristol–Myers Squibb Company reported updated phase 2 clinical data which show that XL184 demonstrated activity in patients with glioblastoma multiforme, the most common and aggressive form of brain cancer. Due to frequent dose interruptions and reductions, the study was amended earlier this year to initiate a new cohort of patients receiving 125mg. As of October 12, 2009, 38 patients have been enrolled at the 125 mg dose level with 18 patients with at least one IRF read post baseline scan.

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