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GlaxoSmithKline and XenoPort, Inc. announced top–line results from a Phase II clinical trial evaluating GSK1838262/XP13512 in adult patients with neuropathic pain associated with post–herpetic neuralgia who have had a history of inadequate response to gabapentin doses of 1800 mg/day or higher. In this double–blind, two–period cross–over study, 3600 mg/day of GSK 1838262 demonstrated a statistically significant improvement over 1200 mg/day of GSK1838262 on the primary endpoint, which was the change from baseline to the end of the treatment period in the 24–hour average pain intensity score.

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