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Scientists from deCODE genetics and academic colleagues from seven countries report the discovery of several novel, common single–letter variations in the sequence of the human genome contributing to risk of osteporosis. By combining and reanalyzing existing data on bone mineral density – the clinical measurement used to diagnose osteoporosis – and hundreds of thousands of SNPs across the genome in more than 19,000 individuals, the study had the statistical power both to identify novel risk variants and to provide validation for many previously found by deCODE.

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