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How important is intestinal cytochrome P450 3A metabolism
Trends in Pharmacological Sciences, 10/14/09

Herwaarden AEV et al. – Cytochrome P450 3A (CYP3A) enzymes metabolize a wide variety of xenobiotics including many drugs. Because CYP3A is localized in both the liver and intestine, it can make a major contribution to the presystemic elimination of substrate drugs after oral administration. However, assessments of the relative importance of intestinal versus hepatic CYP3A–mediated first–pass metabolism have been difficult to make and are subject to extensive discussion.

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