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Thornton KA – Trabectedin is a potential therapeutic option for the management of softtissue sarcoma. It appears to have specific activity in a select group of histologies, most notably myxoid/round cell liposarcoma. Although it would be helpful to study the use of trabectedin in a randomized, controlled fashion, the relative rarity of soft–tissue sarcoma, and heterogeneity of the histologic subtypes, makes phase III trials a difficult prospect.

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