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ACE inhibitors, angiotensin receptor blockers and direct renin inhibitors in combination: a review of their role after the ONTARGET trial
Current Medical Research and Opinion, 08/18/09
Dusing R et al. – ACE inhibitor/ARB combinations showed equivocal effects on clinical outcomes. DRI/ACE inhibitor and DRI/ARB combinations reduced markers of organ damage, but longer–term trials are required to establish whether more complete renin––angiotensin––aldosterone system control with aliskiren–based therapy translates into improved outcome benefits.
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