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DeCODE Discovers a Gene Linked to Risk of Kidney Stones and Osteoporosis
deCODE genetics, 06/30/09

A discovery by scientists at deCODE genetics and academic colleagues from Iceland, the Netherlands and Denmark has pointed to a common biological mechanism contributing to both kidney stones and decreased bone mineral density. About 60% of the population carry two copies of a single-letter variation in the human genome on chromosome 21, putting them at roughly 65% greater likelihood of developing kidney stones than those who carry no copies. This single variant may thus account for more than a quarter of the incidence of kidney stones, and in women carriers it is also associated with decreased BMD at the hip and spine.

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