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When a salmonella contamination hit pistachio nuts a few months ago, FDA moved quickly to recall products and shut down processors. These days, officials are sending out more warning letters, as well as taking bolder enforcement actions and a more proactive approach to health emergencies such as swine flu. Make no mistake: There's a new sheriff in town, and principal deputy commissioner Joshua Sharfstein set the tone early with several high-visibility actions pending confirmation of Margaret Hamburg for the top spot.