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Chromatography-free recovery of biopharmaceuticals through aqueous two-phase processing
Trends in Biotechnology , 04/21/09
Azevedo AM et al. - This review focuses on the use of aqueous two-phase extraction as an option for the downstream processing of therapeutic proteins. It is a potential and promising liquid–liquid extraction technique for the purification of biomolecules, such as monoclonal antibodies, growth factors and hormones, that combines a high selectivity and biocompatibility with an easy scale-up and continuous operation mode.
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