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Peroxynitrite: a strategic linchpin of opioid analgesic tolerance
Trends in Pharmacological Sciences, 03/05/09
Salvemini D et al. - Severe pain syndromes reduce quality of life in patients with inflammatory and neoplastic diseases, partly because the reduced analgesic effectiveness accompanying chronic opiate therapy (i.e. tolerance) leads to escalating doses and distressing side effects. Accordingly, there is major interest in new approaches to maintain opiate efficacy during repetitive dosing without engendering tolerance or causing unacceptable side effects.
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