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The future (or lack of future) of personalized prescription in psychiatry
Pharmacological Research , 02/04/09
Leon JD et al. - The author thinks that, in psychiatry, pharmacogenetic tests have some potential in two areas: excluding some drugs for some unusual patients, and using pharmacokinetic genes for personalizing dosing in narrow therapeutic window drugs. In the short term, there is dubious potential for other pharmacogenetic tests and no potential for pharmacogenetic testing to ascertain the best drug for each patient. Personalized dosing has immediate application if one understands it as the use of our current scientific knowledge of genetic, environmental and personal variables to determine dosing; its sole requirement is well-trained psychiatrists.
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