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Pseudolymphomatous reaction to varicella zoster virus vaccination: role of viral in situ hybridization
Journal of Cutaneous Pathology, 11/06/09

Abbott JJ et al. – The findings are consistent with a pseudolymphoma (PL), a reactive inflammatory disorder that can resemble cutaneous lymphoma and has rarely been described in herpes infections and post–herpetic scars. In situ hybridization studies for VZV were performed and highlighted occasional deep fibroblasts with nuclear positivity for VZV DNA. A review of post–vaccination reactions and herpes–related PL is discussed with emphasis on using in situ hybridization in establishing the diagnosis.

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