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Prevalence and distribution of solitary oral pigmented lesions: a prospective study
Journal of the European Academy of Dermatology and Venereology, 10/27/09

De G et al. – Solitary pigmented lesions are uncommon in the oral mucosa. There is some difficulty in distinguishing between a benign pigmented lesion and a growing melanoma which, though rare (1% of all oral malignancies), is a serious and often fatal disease. Therefore, biopsy with histological exam represents the diagnostic gold standard.

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