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Association of the toll-like receptor 2 A-16934T promoter polymorphism with severe atopic dermatitis
Allergy, 10/13/09
Oh DY et al. – Atopic dermatitis (AD) is a chronic inflammatory skin disease with a multifactorial pathogenesis and increasing incidence in the Western world. A genetically determined defective function of pattern recognition receptors such as toll–like receptors (TLRs) has been proposed as a candidate mechanism in the pathogenesis of AD. Aim: These data indicate that TLR2 is relevant for the phenotype of severe AD in adults.
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