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Histamine induces human beta-defensin-3 production in human keratinocytes
Journal of Dermatological Science, 10/07/09
Ishikawa T et al. – It is suggested that histamine induces hBD–3 production in human keratinocytes through H1 receptors by activating STAT3 and AP–1 via JAK2 and MEK/ERK. Histamine may promote cutaneous antimicrobial defense, inflammation, and wound repair through hBD–3.
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