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See Latest ArticlesTargeted high-resolution ultrasound is not an effective substitute for sentinel lymph node biopsy in patients with primary cutaneous melanoma
Journal of Clinical Oncology, 10/02/09
Sanki A et al. – US is not an appropriate substitute for SLN biopsy, but it is of value in preoperative SLN assessment and postoperative monitoring.
Methods- US performed on SLNs identified in 871 lymph node fields in 716 patients
- SLN biopsy performed within 24 hours of lymphoscintigraphy and US examination
- The CSA of SLN metastatic deposit determined sonographically and histologically
- Sensitivity of targeted US in detection of positive SLNs was 24.3% and specificity was 96.8%
- Sensitivity was highest for neck SLNs (45.8%) and improved with greater Breslow thickness
- Median histologic CSA of SLN metastatic deposits 0.39 mm2 (12.75 mm2 for US true-positive results and 0.22 mm2 for US false-negative results
- True-positive, US-detected SLNs had significantly greater CSAs than undetected SLN metastases and were more likely to be spherical in cross-section
- More than two sonographic descriptors of SLN metastases or rounding of node alone were factors highly suggestive of melanoma deposit
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