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See Latest ArticlesInhibition of Rac1 GTPase downregulates vascular endothelial growth factor receptor-2 expression by suppressing Sp1-dependent DNA binding in human endothelial cells
Experimental Dermatology, 09/21/09
Meissner M et al. – Electrophoretic mobility shift assays demonstrated that constitutive Sp1–dependent DNA binding decreased with Rac1 inhibition. Hence, repression of the small Rho GTPase Rac1 seems to be an additional critical molecular mechanism in the regulation of VEGFR2 expression.
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