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Methylation-associated silencing of S100A4 expression in human epidermal cancers
Experimental Dermatology, 09/21/09
Li Y et al. – The authors findings demonstrate that S100A4 downregulation, as the consequence of DNA methylation, is closely correlated with skin tumor formation. Wnt activation and E–cadherin reduction and S100A4 down–regulation are paralleled molecular events in skin tumors, which may serve as the biomarkers for predicting epidermal cancer risk.
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