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Modeling signaling pathways leading to wrinkle formation: Identification of the skin aging target
Indian Journal of Dermatology, Venereology and Leprology , 09/14/09

Chauhan P et al. – Stressors like UV irradiation, osmotic stress and heat shock have been reported to activate epidermal growth factor receptor, interleukin 1 receptor, tumor necrosis factor receptor, platelet–derived growth factor receptor and platelet activation factor receptor signaling pathways, which lead to the production of matrix metalloproteinases, collagen degradation and, consequently, wrinkle formation. When all the five signaling pathways were modeled, the c–jun part of the AP–1 transcription factor was found to be a common intermediate protein involved in all the signaling cascades.

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