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IL-6 Signaling in Psoriasis Prevents Immune Suppression by Regulatory T Cells
Journal of Immunology, 08/26/09
Goodman WA et al. – T lymphocytes trafficking into lesional psoriatic skin encounter high IL–6 from endothelial cells, DCs, and Th17 cells, enabling cutaneous T cell escape from Treg suppression and Th17 participation in inflammation. Targeting IL–6 signaling pathways in psoriasis may rebalance Treg/T effector activity and ameliorate disease.
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