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Bebo BF et al. – Topical therapy is the first–line recommended treatment for mild to moderate disease. For moderate to severe disease, phototherapy and antiretrovirals are the recommended first–line therapeutic agents. Oral retinoids may be used as second–line treatment. For more refractory, severe disease, cautious use of cyclosporine, methotrexate, hydroxyurea, and tumor necrosis factor–alpha inhibitors may also be considered.

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