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Buback F et al. – OPN is secreted in autoimmune diseases such as lupus erythematosus, and influences inflammation of immediate and delayed type allergies and granuloma formation. The authors describe that OPN is overexpressed in psoriasis and propose a model to study OPN function in psoriatic inflammation. Through cytokine functions, OPN supports immune responses against Mycobacteria and viruses such as herpes simplex virus. OPN is also implicated in skin tumor progression. Overexpression of OPN influences invasion and metastasis of melanoma and squamous cell carcinoma cells, and OPN expression in melanoma is a possible prognostic marker.

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Today in Derm Allergy/Immunology...keeping you current

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Today in Dermatologic Oncology...keeping you current

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Today in Psoriasis...keeping you current

Methotrexate versus traditional Chinese medicine in psoriasis: a randomized, placebo-controlled trial to determine efficacy, safety and quality of life
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Fluorescence remission spectroscopy of psoriatic lesions and the effect of topical anthralin therapy
Journal of the European Academy of Dermatology and Venereology, 11/24/09


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