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Wollina U – Pompholyx is an inflammatory vesicobullous disorder of the palms and soles. Pompholyx treatment is challenging: topical therapy is based on corticosteroids and calcineurin inhibitors. Topical and systemic photochemotherapy and high–dose UVA–1 irradiation have been successfully used. Systemic therapy is often necessary in advanced cases of pompholyx. Corticosteroids are commonly used, sometimes combined with immunosuppressants. Alitretinoin has efficacy in chronic hand eczema including pompholyx. Another evolving treatment seems to be the intradermal injection of botulinum toxin. Prevention requires antibiosis in case of suspected secondary infection and aggressive anti–inflammatory treatment.

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