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Uitto J – A bimetal, 0.1% copper–zinc malonate–containing cream, has recently been shown to improve the appearance of sun–damaged facial skin when applied twice daily for up to 6–8 weeks. This improvement was accompanied by repair of the elastic fiber network. While the precise mechanisms of these regenerative processes are not clear at present, this compound appears to lead to clinical improvement through its effects on the expression of the elastin gene in the dermis.

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