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Yamamoto Y et al. – The authors present the case of a 9–month–old boy with yellow–brown papules that gradually increased in number over a period of 6 months without systemic involvement. This case was clinicopathologically diagnosed as S–100–positive juvenile xanthogranuloma, and longitudinal observation revealed that strong S–100 reactivity disappeared in parallel with maturation of the lesions within 2 years after the initial diagnosis.

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