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FLG mutation p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese patients with atopic eczema
British Journal of Dermatology, 08/18/09

Nemoto–Hasebe I et al. – The authors clearly demonstrated that FLG mutations are significantly associated with AE in the Japanese population. The present results further support the hypothesis that the C–terminal region is essential for proper processing of profilaggrin to filaggrin.

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