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See Latest ArticlesPaucity of intraepidermal FoxP3-positive T cells in cutaneous T-cell lymphoma in contrast with spongiotic and lichenoid dermatitis
Journal of Cutaneous Pathology, 08/10/09
Wada DA et al. – FoxP3–positive T cells are less frequently encountered in MF than in inflammatory dermatoses. FoxP3–positive T cells occur in higher proportions in the dermis than in the epidermis and probably correlate with coexisting inflammatory components. CTCL neoplastic cells do not typically express a Treg phenotype and are associated with low numbers of FoxP3–positive Tregs in the infiltrate. FoxP3 expression by immunohistochemistry may aid histologic evaluation of these conditions.
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