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See Latest ArticlesReduced Expression of Connective Tissue Growth Factor (CTGF/CCN2) Mediates Collagen Loss in Chronologically Aged Human Skin
Journal of Investigative Dermatology, 08/06/09
Quan TH et al. – The data indicate that in human skin fibroblasts, type I procollagen expression is dependent on endogenous production of both TGF–beta and CTGF, which act through interdependent yet distinct mechanisms. Downregulation of the TGF–beta/Smad/CTGF axis likely mediates reduced type I procollagen expression in aged human skin in vivo.
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Basic fibroblast growth factor stimulates the proliferation of human dermal fibroblasts via the ERK1/2 and JNK pathways
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