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See Latest ArticlesThe expression and phosphorylation of eukaryotic initiation factor 4E are increased in lesional psoriatic skin
British Journal of Dermatology, 07/31/09
Kjellerup RB et al. – The authors have demonstrated for the first time that the level of total and phosphorylated eIF4E and the expression of 4E–BP1 are increased in lesional psoriatic skin. As eIF4E–regulated proteins have been reported to be upregulated in psoriasis, it appears that the increase in eIF4E is only incompletely counteracted by 4E–BP1. Therefore, eIF4E might contribute to the pathogenesis of psoriasis.
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