Dermatology Medical News about keloids, Topical tamoxifen

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Topical tamoxifen therapy in hypertrophic scars or keloids in burns
Archives of Dermatological Research, 07/30/09

Gragnani A et al. – The addition of tamoxifen, a non–steroidal anti–estrogen, usually used in breast cancer, to standard treatment may lead to improved wound healing in keloids by decreasing the expression of TGF–beta–1, with the consequent inhibitions of both fibroblast proliferation and collagen production. Topical tamoxifen citrate chemical treatment has been shown to improve scarring. However, prospective studies must be undertaken to validate the inclusion of tamoxifen into standard clinical practice.

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