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See Latest ArticlesCoexpression of major histocompatibility complex class II with chemokines and nuclear NF[kappa]B p50 in melanoma: a rational for their association with poor prognosis
Melanoma Research, 07/29/09
Martins I et al. – The molecular basis for class II transactivator and HLA–DR expression in melanoma therefore remains unsolved, but the findings linking together the expression of HLA–DR, of chemokines involved in invasiveness, and of nuclear NFkB p50 strongly support the content that MHC II may be a marker of invasive primary melanoma, and could explain the long–standing association of MHC II expression with overall poor prognosis and unfavorable clinical outcome.
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