Dermatology Medical News about Melanomas, NGFR, Perineural invasion

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Low-affinity nerve growth factor receptor (P75 NGFR) as a marker of perineural invasion in malignant melanomas
Journal of Cutaneous Pathology, 07/23/09

Chan MM et al. - P75 nerve growth factor receptor (NGFR) may play a mechanistic role in invasive malignant melanomas (MMs) demonstrating perineural invasion (PNI). Its expression may serve as a marker of PNI in those tumors that lack histological evidence of nerve involvement.

Methods

Study sought to investigate the mechanism of PNI that is associated with increased local recurrences and metastases
Hypothesis that P75 NGFR, a nerve growth factor receptor, may be implicated in the pathogenesis of PNI was tested
IHC staining for P75 NGFR was performed on 47 skin tumors with PNI including invasive squamous cell carcinomas (SCCs), basal cell carcinomas (BCCs), and malignant melanomas (MMs)
These were compared with similar lesions w/o PNI

Results

P75 NGFR staining was absent in all invasive SCCs irrespective of the presence of PNI
2 BCCs with PNI and 3 w/o PNI showed focal P75 NGFR staining
8 of 10 invasive MMs with PNI had positive P75 NGFR expression vs only 1 of 9 w/o PNI

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