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Psoriasis is a chronic, immune-mediated inflammatory skin disease that affects approximately 2–3% of the world’s population. For many patients, it is a lifelong condition; 20–30% of patients will have severe psoriasis and will often require systemic therapy to achieve disease control. Methotrexate was first introduced as a treatment for psoriasis over 50 years ago and, in spite of the development of many new biological treatments, it remains the gold standard systemic therapy for psoriasis in Europe.

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