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See Latest ArticlesThe critical role of alpha-folate receptor in the resistance of melanoma to methotrexate
Pigment Cell & Melanoma Research, 06/29/09
Sánchez-del-Campo L et al. - FR-alpha-induced endocytic transport of MTX, together with drug melanosomal sequestration and cellular exportation, ensures reduced accumulation of this cytotoxic compound in intracellular compartments. The critical role of FR-alpha in this mechanism of resistance and the therapeutic consequences of these findings are also discussed.
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