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See Latest ArticlesMethotrexate-related lymphoproliferative disorder with extensive vascular involvement in a patient with rheumatoid arthritis
Journal of the American Academy of Dermatology, 06/25/09
Shimura C et al. - The authors describe the development of a cutaneous lymphoproliferative disorder in a patient with rheumatoid arthritis who was treated with methotrexate. Skin manifestations were characterized by thrombophlebitis-like lesions and ulcerated nodules. Histologic examination revealed large polymorphic atypical cells including Reed-Sternberg–like cells expressing CD20 and CD30 in the dermis and subcutaneous tissues.
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