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Impact of Scratching on Itch and Sympathetic Reflexes Induced by Cowhage (Mucuna pruriens) and Histamine
Acta Dermato-Venereologica, 06/24/09

Kosteletzky F et al. - Cowhage and histamine, both applied via spicules, were used to induce itch. The quality and intensity of the sensations, axon reflex flare, sympathetic skin vasoconstrictions and the interference of scratching with itch processing were studied. The findings support the notion that both agents activate different pathways. The differences in sympathetic reflex induction and in the modulation by scratching indicate differential central nervous processing.

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