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Ranki A - Letterer-Siwe disease (LSD) is the disseminated multisystemic form of LCH and often, the course of LSD is rapid and fatal. However, LCH is also found in adults of all ages, although less often. Most adult patients will survive LCH but in some cases, the disease may run a progressive course and can be life threatening. Why do the Langerhans' cells proliferate is not known, and since LCH is so rare, very little research has been directed into its cause and treatment.


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