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Predictive Factors of Regional Toxicity and Serum Creatine Phosphokinase Levels After Isolated Limb Infusion for Melanoma: A Multi-Institutional Analysis
Annals of Surgical Oncology, 06/23/09

Santillan AA et al. - ILI can be performed with an acceptable morbidity. Papaverine use, female gender, and high peak CK were associated with higher limb toxicity. CK levels can be diminished significantly with aIBW.

Exclusive Author Commentary
Jonathan S. Zager, 06/24/09

Isolated limb Infusion or ILI is a method of regionally delivering chemotherapy to a limb in order to treat recurrent, unresectable intransit melanoma or limb threatening sarocmas. The procedure, developed in order to provide a regional therapeutic option that would potentially be less morbid and less complex than the hyperthermic isolated limb perfusions, has had much success in treating these difficuly clinical scenarios. Although considered minimally invasive (or a low flow minimally invasive hyperthermic limb perfusion), there is considerable morbidity assocaited with it. We have demonstrated that correcting the dose of meplhalan for ideal body wieght will decrease the severity of regional toxicity wihtout adversely affecting the overall response rates (Beasley et al JACS 2009).

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