Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. 2008 Exclusive Survey—Earnings: Good news for primary care income 3. Medicare pay-for-reporting effort draws fire from frustrated doctors 4. Debunking Myths in the US Healthcare System 5. Doctors and the DEA Free full text
Top Ten Searches
rosacea eczema alopecia ceramide keratosis pityriasis basal cell melanoma keratosis purpuraYour Article Summary
See Latest ArticlesDivergent cancer pathways for early-onset and late-onset cutaneous malignant melanoma
Cancer, 06/29/09
Anderson WF et al. - In a trial to discern the timing and/or age of exposure for cutaneous malignant melanomas (CMM), current results were consistent with a divergent and age-dependent solar hypothesis for CMM. Early-onset melanomas may represent gene-sun exposure interactions that occur early in life among susceptible individuals. Late-onset melanomas may reflect accumulated, lifelong sun exposure in comparatively less susceptible individuals.
Methods- Effect of aging on CMM incidence were systematically examined in data from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.
- Standard descriptive epidemiology was supplemented with mathematical models.
- Impact of advancing age on CMM incidence was assessed by sex, histopathologic classification (superficial spreading melanoma [SSM] or lentigo maligna melanoma [LMM]), and anatomic site (face, head, and neck [FHN] or lower extremity [LE]).
- Sex, histopathology, and anatomic site were age-specific effect modifiers for CMM that indicated divergent (bimodal) early-onset and late-onset cancer pathways.
- Early-onset melanomas were associated predominantly with women, SSM, and LE.
- Late-onset melanomas were correlated with men, LMM, and FHN.
- Early- and late-onset melanoma populations were confirmed with age-period-cohort models that were adjusted for period and cohort effects.
- 2-component mixture models also fit the data better than a single cancer population.
Today in Dermatologic Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
A practical approach to using methotrexate
Dermatology in Practice, 10/09/09
Positron emission tomography in early detection of relapse in high-risk melanoma patients: a retrospective review
Community Oncology , 10/09/09
Surgical excision margins for primary cutaneous melanoma
Cochrane Reviews, 10/09/09
Sponsor
Article Search
Sponsor