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Thioguanine Nucleotides and Thiopurine Methyltransferase in Immunobullous Diseases
Archives of Dermatology, 06/22/09

El-Azhary RA et al. - Optimal levels of 6-thioguanine nucleotide metabolites for disease remission in dermatology patients are 150 to 300 pmol/8 x 108 RBCs. High levels of the inactive metabolite 6-methylmercaptopurine and induction of thiopurine methyltransferase are associated with recalcitrant disease.

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