Dermatology Medical News about Urticaria pigmentosa

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Urticaria pigmentosa associated with acute stress and lesional skin mast-cell expression of CRF-R1
Clinical and Experimental Dermatology, 06/16/09

Theoharides TC et al. - A 38-year-old woman presented with a pronounced increase in symptoms and proliferation of urticaria pigmentosa (UP) after acute psychological stress, which was quantified using the Spielberger's State-Trait Anxiety Inventory. Immunohistochemical examination of a skin biopsy from a new UP lesion showed a large number of activated mast cells expressing corticotrophin-releasing factor receptor-1 (CRF-R1) and there was high serum CRF.

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