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Tokura Y - Photosensitive chemicals have a haptenic moiety, and two hypotheses have been put forward to explain the formation of photoallergens: prohaptens and photohaptens. Photohaptens need to coexist with a protein and, upon UV irradiation, a covalent bond is formed. The vast majority of clinically photoallergic chemicals are photohaptens rather than prohaptens.

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