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Hay RMA et al. - The use of PTX and SSZ as adjuvant therapy in the treatment of PV induced a faster and more significant decrease in the serum level of TNF-alpha, and this decrease was associated with rapid clinical improvement.

Exclusive Author Commentary
Mohammad El Darouti, 05/26/09

the use of cheap anti tumor necrosis factors (pentoxyphillin and sulphazalazine) proved to be good adjuvant therapy for treatment of autoimmune bullous disorders including (PV, bullous pemphigoid, cicatricial pemphigoid and epidermolysis bullosa acquisita): 1) with use of PTX and SZS patients do not have to use daily steroids (the full regimen is illustrated in the paper) 2) the use of both PTX and SZS is not associated with any major side effects and is very safe to use 3) Recently we have PTX infusion 400 mg IV T.i.d for the treatment of refractory cases of PV and cicatricial pemphigoid with impressive initial results therefore both PTX and SZS proved to be very effective anti TNF agents and steroid sparing agents

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