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Philipp CM et al. - The finding of a recovery-fluorescence suggests excess amount of 5-ALA in the lesions, deeper penetration of 5-ALA with extended incubation times, local persistence of viable cells being able to produce PpIX after first irradiation, a need for an individualized light and drug dosimetry including prolonged incubation times, repeated irradiation and fluorescence control during topically ALA-induced PpIX-PDT.


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