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ALA or MAL for photodynamic therapy and fluorescence diagnosis
Medical Laser Application, 05/19/09
Krammer B - Aminolevulinic acid (ALA) is the precursor of the potent photosensitizer protoporphyrin IX (PpIX) in the heme biocycle. If ALA is given externally to cells, they generate PpIX in excess, which cannot be quickly converted to the end product heme and therefore remains available as sensitizer for a limited time.
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