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A Scleroderma-Like Cutaneous Syndrome Associated With a Marked Th2-Type Immune Response Occurring After a Prosthetic Joint Implant
Journal of Clinical Rheumatology (JCR), 04/17/09
Romano C et al. - A scleroderma-like cutaneous syndrome, occurring after implantation of a prosthetic knee joint in an elderly woman, is reported. This case did not seem to typically fit into any of the known scleroderma-like disorders of the skin described to date. The patient was shown to be sensitized to metals contained in the prosthesis and to mount a Th2-type immune response concomitantly with development of skin fibrosis.
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