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Ghosh SK et al. - A rapid, reliable and in vivo test to distinguish between patients with and those without circulating functional autoantibodies would be of value to diagnose autoimmune urticaria and also to evaluate the effectiveness of immunomodulatory treatment. Intradermal injection of autologous serum in some patients can induce weal and flare response. This observation had led to the recognition of circulating autoantibodies in chronic urticaria and provides the basis of autologous serum skin test (ASST).

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