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The diagnosis of Sezary syndrome on peripheral blood by flow cytometry requires the use of multiple markers
British Journal of Dermatology, 09/29/08
Klemke CD et al. - The combination of identifying CD4+ CD7-CD3dim cells, TCR-V[beta] chain and CD158k expression allowed a definite identification of SS-defining blood involvement in every individual patient. All of these markers can be measured by flow cytometry which would avoid time-consuming analysis of blood smears. These markers would also be suitable to monitor tumour cell load during therapy.
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